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Dr. Meg Explains
"L-Ergothionine is an interesting amino acid that is not well known in Europe. I am passionate about longevity and aesthetics, so I want to demystify some findings we have been excited about recently in medical research communities"
Ergothioneine: A Vitamin with Antiaging and Neuroprotective Roles?
Educational summary by Dr. Srinivasa, Medical Advisor, and team. Based on Paul B.D. (2022), DOI 10.1089/ars.2021.0043. Educational only, no product endorsement. Ergothioneine (EGT), a naturally occurring amino acid, has recently gained attention for its potential health benefits, particularly in the realms of antiaging and neuroprotection. Trace amounts are found in foodstuffs such as certain mushrooms. It is considered a vitamin because it has a role in metabolism (function
4 min read
Ergothioneine and Exercise: How One Molecule Helps Muscles Recover and Endure
Educational summary by D r. Srinivasa, Medical Advisor, and team. Based on Sprenger H-G et al. (2025), Cell Metabolism , DOI 10.1016/j.cmet.2025.01.024. Educational only, no product endorsement. Exercise is one of the most effective ways to maintain long-term health and slow biological aging, but it also creates intense metabolic stress. When muscles work hard, they burn oxygen rapidly, producing reactive oxygen species (ROS). In small amounts, ROS help trigger beneficial a
3 min read
Ergothioneine and Heart Health: How One Natural Molecule Protects Blood Vessels and the Cardiovascular System
Educational summary by Dr Srinivasa, Medical Advisor, and team. Based on Servillo L. et al. (2017), DOI: 10.1097/FJC.0000000000000464. Educational only, no product endorsement. The heart and blood vessels are constantly exposed to environmental toxins. Things such as high blood sugar, stress, poor diet, and even everyday metabolic reactions generate oxidizing toxins that can damage the lining of blood vessels. This "oxidative stress" is a root cause of many cardiovascular d
4 min read
Ergothioneine and Immune Balance: How a Natural Antioxidant Helps Fine-Tune Immunity
Educational summary by Dr. Srinivasa, Medical Advisor, and team. Based on Yoshida S. et al. (2017), DOI 10.1371/journal.pone.0169360 Educational only, no product endorsement. The immune system relies on a delicate balance. When threats appear, specialized immune cells called "macrophages" sound the alarm by releasing "cytokine" messengers to recruit reinforcements. However, a balanced response is needed. Too weak, infections linger; too strong, and the body can damage its o
3 min read
Ergothioneine and Liver Health: How a Natural Antioxidant Protects and Repairs the Liver
Educational summary by Dr. Srinivasa, Medical Advisor, and team. Based on Mao Y. et al. (2025), Journal of Applied Toxicology, DOI doi.org/10.1002/jat.4728 . Educational only, no product endorsement. The liver is a multi-functioning powerhouse. It filters toxins, processes nutrients, and helps regulate metabolism. But chronic injury from alcohol, fat buildup, viruses, or drugs can trigger liver fibrosis, a slow scarring process that can lead to cirrhosis (fatty liver). Fibro
3 min read
Ergothioneine and Age-Related Macular Degeneration: Protecting the Eye from Oxidative Stress
Educational summary by Dr. Srinivasa, Medical Advisor, and team. Based on Gu S. et al., Experimental Eye Research (2024), DOI 10.1016/j.exer.2024.109862 . Educational only, no product endorsement. Age-related macular degeneration (AMD) is one of the leading causes of irreversible vision loss in older adults. In roughly 90 % of AMD cases, cells in the eye's retinal pigment epithelium (RPE) gradually deteriorate under continuous "oxidative stress". These RPE cells act as the
3 min read
L-Ergothioneine and Skin Longevity: How One Molecule Helps Your Skin Age Better
Educational summary by Dr. Srinivasa, Medical Advisor, and team. Based on Hseu Y.C. (2020), DOI 10.1155/2020/2576823 . Educational only, no product endorsement. Ergothioneine (EGT), is an amino acid found in small quantities in certain foods. Recently some interesting studies of its possible longevity benefits in humans have been done on skin. Here we will demystify an exciting research study on the relationship between EGT and skin aging. Short Summary of Findings Here is
3 min read
Ergothioneine and Sleep Quality: A Natural Antioxidant that Helps the Brain Rest Better
Educational summary by Dr. Srinivasa, Medical Advisor, and team. Based on Katsube M. et al. (2022), DOI 10.1016/j.jff.2022.105165. Educational only, no product endorsement. Sleep problems are increasingly common in modern life. Stress, late-night screens, and irregular schedules can disturb the delicate balance of brain chemistry that controls rest and recovery. L-Ergothioneine (EGT) is an amino acid that can be found in trace amounts in some foods. Researchers have suspecte
3 min read
L-Ergothioneine and Cognitive Function: How One Molecule Supports Brain Health
Educational summary by Dr. Srinivasa, Medical Advisor, and team. Based on Ishimoto T. (2022), DOI 10.1002/1873-3468.14271. Educational only, no product endorsement. L-Ergothioneine (EGT) is a naturally occurring amino acid found in trace amounts in foods such as mushrooms, beans, and oats. Research in recent years has explored how this unique nutrient may influence brain health and cognitive performance. In this post, we summarise a 2022 research review article from Kanazawa
3 min read
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